Regulation of blood glucose agent VT021(PM021)


Diabetes mellitus (DM), commonly known as diabetes, is a group of metabolic disorders characterized by high blood sugar levels over a prolonged period. Symptoms of high blood sugar include frequent urination, increased thirst, and increased hunger. If left untreated, diabetes can cause many complications. Acute complications can include diabetic ketoacidosis, hyperosmolar hyperglycemic state, or death.

Diabetes is due to either the pancreas not producing enough insulin, or the cells of the body not responding properly to the insulin produced. There are three main types of diabetes mellitus:
Type 1 DM results from the pancreas' failure to produce enough insulin due to loss of beta cells. The cause is unknown.
Type 2 DM begins with insulin resistance, a condition in which cells fail to respond to insulin properly.As the disease progresses, a lack of insulin may also develop.

The most common cause is a combination of excessive body weight and insufficient exercise.Gestational diabetes is the third main form, and occurs when pregnant women without a previous history of diabetes develop high blood sugar levels.


In 2017, 425 million people had diabetes worldwide, up from an estimated 382 million people in 2013 and from 108 million in 1980. Accounting for the shifting age structure of the global population, the prevalence of diabetes is 8.8% among adults, nearly double the rate of 4.7% in 1980. Type 2 makes up about 90% of the cases. Some data indicate rates are roughly equal in women and men, but male excess in diabetes has been found in many populations with higher type 2 incidence, possibly due to sex-related differences in insulin sensitivity, consequences of obesity and regional body fat deposition, and other contributing factors such as high blood pressure, tobacco smoking, and alcohol intake.

The global number of diabetes cases might increase by 48% between 2017 and 2045.


We checked natural extracts and found that the Mori Folium and Aurantii Fructus Immaturus mixture showed the best anti-Diabetes results.

Draw a significant results from pre-clinical animal models and semi-health clinical trials

Excellent safety and stability of raw materials

Mori Folium, Aurantii Fructus Immaturus extract mixture is recognized as a functional ingredient of health functional food (MFDS, 2010-33)

Classification PIPELINE Candidate material Preclinical Clinical trial New Drug approval Item authorization
1 2 3
Botanical substance functional material
(Health functional food)
Regulation of
blood glucose VT021(PM021)
  • Individually-approved health functional food Item authorization (2010-33)

Completed development of candidate materials, pre-clinical development phase

  • Diabetes Res Clin Pract. 2011 Aug;93(2):198-204 (IF:3.639)

    Anti-diabetic effect of standardized herbal formula PM021 consisting of Mori Folium and Aurantii Fructus on type II diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats


Diabetes treatment material containing Aurantii Fructus Immaturus extract and health supplement food with their active ingredient (registration number : 10009401330000, 2010.01)

Permitted articles

Mori Folium, Aurantii Fructus Immaturus extract mixture that can help Regulation of blood glucose (MFDS, 2010 – 33)

혈당조절제 (PM021) 예시 이미지